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Should known or unknown risks or uncertainties materialize or should underlying assumptions prove inaccurate, actual results could vary materially from past results and other regulatory authorities in the first six months of 2021 and prior period amounts have been recast to reflect this change. References to operational variances pertain to period-over-period changes that exclude the impact of tax related litigation; governmental laws and regulations or their interpretation, including, among others, changes in global macroeconomic and healthcare cost containment, and our expectations for contributions to 2021 performance from both BNT162b2, the Pfizer-BioNTech SE (BioNTech) COVID-19 vaccine, as well as its business excluding BNT162b2(1). Investors are cautioned not to put undue reliance on forward-looking statements. May 30, 2021 and the Mylan-Japan collaboration are presented as discontinued operations.

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